Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Weighted sum of harmonic signals for direct imaging in magnetic particle imaging | |
Liu, Yanjun1,2,3,4,5 ; Hui, Hui4,5,6; Liu, Sijia4,5,7; Li, Guanghui1,2,3,4,5; Zhang, Bo1,2,3,4,5; Zhong, Jing8; An, Yu1,2,3,4,5; Tian, Jie1,2,3,4,5,7,9
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| Source Publication | PHYSICS IN MEDICINE AND BIOLOGY
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| ISSN | 0031-9155 |
| 2023-07-01 | |
| Volume | 68Issue:1Pages:13 |
| Corresponding Author | Hui, Hui(hui.hui@ia.ac.cn) ; Tian, Jie(tian@ieee.org) |
| Abstract | Objective. Magnetic particle imaging (MPI) is a novel radiation-free medical imaging modality that can directly image superparamagnetic iron oxide tracers (SPIOs) with high sensitivity, temporal resolution, and good spatial resolution. The MPI reconstruction task can be formulated mathematically as a Fredholm integral problem, but the concrete inversion is not easily possible because of the particle dynamics or scanner issues. Measurement based system matrix inversion takes these factors into account, but prior measurement and calibration are time consuming. Approach. We proposed a direct imaging method based on the weighted sum of harmonic signals. The harmonic signals with spatial information are obtained by the short-time Fourier transform, and odd harmonic components are selected for recombination and then mapped to the sampling trajectory to image the concentration distribution of SPIOs. In addition, we adopt a normalized-weighted sum of harmonics to improve the resolution of the native image. Main results. The effectiveness of the proposed method is verified by simulation imaging experiments and our in-house scanner-based experiments. Quantitative evaluation results show that compared with traditional methods, the structural similarity improved by 48%, mean square error decreased by 88%, and signal-to-artifact ratio increased by 2.5 times. Significance. The proposed method can rapidly image the concentration distribution of nanoparticles without any prior calibration measurements and reduce the blur of MPI images without deconvolution, which has the potential to be implemented as a multi-patch imaging method in MPI. |
| Keyword | magnetic particle imaging short-time fourier transform direct imaging multi-patch imaging |
| DOI | 10.1088/1361-6560/aca9b9 |
| WOS Keyword | RECONSTRUCTION ; NANOPARTICLE ; PERFORMANCE ; AMPLITUDE ; TRACER ; MOTION |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2017YFA0700401] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; CAS Youth Innovation Promotion Association[2018167] ; CAS Key Technology Talent Program ; Guangdong Key Research and Development Program of China[2021B0101420005] ; Project of High-Level Talents Team Introduction in Zhuhai City[Zhuhai HLHPTP201703] |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Youth Innovation Promotion Association ; CAS Key Technology Talent Program ; Guangdong Key Research and Development Program of China ; Project of High-Level Talents Team Introduction in Zhuhai City |
| WOS Research Area | Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000904747700001 |
| Publisher | IOP Publishing Ltd |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/51082 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Hui, Hui; Tian, Jie |
| Affiliation | 1.Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China 2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China 3.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol Peoples Republ China, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Southeast Univ, Sch Comp Sci & Engn, Nanjing 210096, Peoples R China 8.Beihang Univ, Sch Instrumentat & Optoelect Engn, Beijing 100191, Peoples R China 9.Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr, Zhuhai 519000, Peoples R China |
| First Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Corresponding Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Yanjun,Hui, Hui,Liu, Sijia,et al. Weighted sum of harmonic signals for direct imaging in magnetic particle imaging[J]. PHYSICS IN MEDICINE AND BIOLOGY,2023,68(1):13. |
| APA | Liu, Yanjun.,Hui, Hui.,Liu, Sijia.,Li, Guanghui.,Zhang, Bo.,...&Tian, Jie.(2023).Weighted sum of harmonic signals for direct imaging in magnetic particle imaging.PHYSICS IN MEDICINE AND BIOLOGY,68(1),13. |
| MLA | Liu, Yanjun,et al."Weighted sum of harmonic signals for direct imaging in magnetic particle imaging".PHYSICS IN MEDICINE AND BIOLOGY 68.1(2023):13. |
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