Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows

doi:10.1245/s10434-023-14677-9

	Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows
	Mi, Jiahui 1; Li, Changjian 2,3; Yang, Feng 1; Shi, Xiaojing4,5 ; Zhang, Zeyu2,3 ; Guo, Lishuang 2,3; Jiang, Guanchao 1; Li, Yun 1; Wang, Jun 1; Yang, Fan1 ; Hu, Zhenhua4,5 ; Zhou, Jian 1
发表期刊	ANNALS OF SURGICAL ONCOLOGY
ISSN	1068-9265
	2023-12-08
页码	10
通讯作者	Yang, Fan(yangfan@pkuph.edu.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Zhou, Jian(zhoujian@bjmu.edu.cn)
摘要	Background We compare the application of intravenous indocyanine green (ICG) fluorescence imaging in lung cancer with near-infrared-I (NIR-I) and near-infrared-II (NIR-II) windows.Methods From March to December 2022, we enrolled patients who received an intravenous injection of ICG (5 mg/kg) 1 day before the planned lung cancer surgery. The lung cancer nodules were imaged by NIR-I/II fluorescence imaging systems, and the tumor-to-normal-tissue ratio (TNR) was calculated. In addition, the fluorescence intensity and signal-to-background ratio (SBR) of capillary glass tubes containing ICG covered with different thicknesses of lung tissue were measured by NIR-I/II fluorescence imaging systems.Results In this study, 102 patients were enrolled, and the mean age was 59.9 +/- 9.2 years. A total of 96 (94.1%) and 98 (96.1%) lung nodules were successfully imaged with NIR-I and NIR-II fluorescence, and the TNR of NIR-II was significantly higher than that of NIR-I (3.9 +/- 1.3 versus 2.4 +/- 0.6, P < 0.001). In multiple linear regression, solid nodules (P < 0.001) and squamous cell carcinoma (P < 0.001) were independent predictors of a higher TNR of NIR-I/II. When capillary glass tubes were covered with lung tissue whose thickness was more than 2 mm, the fluorescence intensity and the SBR of NIR-II were significantly higher than those of NIR-I.Conclusions We verified the feasibility of NIR-II fluorescence imaging in intravenous ICG lung cancer imaging for the first time. NIR-II fluorescence can improve the TNR and penetration depth of lung cancer with promising clinical prospects.
关键词	Indocyanine green Near-infrared-II windows Fluorescence imaging Lung cancer surgery Clinical application
DOI	10.1245/s10434-023-14677-9
关键词[WOS]	FLUOROPHORES ; NODULES ; IDENTIFICATION ; RESECTION
收录类别	SCI
语种	英语
资助项目	CAS Youth Interdisciplinary Team ; National Natural Science Foundation of China[82003316] ; National Natural Science Foundation of China[92059203] ; National Natural Science Foundation of China[92059207] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; Fundamental Research Funds for the Central Universities[JKF-YG-22-B005] ; [JCTD-2021-08]
项目资助者	CAS Youth Interdisciplinary Team ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
WOS研究方向	Oncology ; Surgery
WOS类目	Oncology ; Surgery
WOS记录号	WOS:001117873100008
出版者	SPRINGER
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/54968
专题	中国科学院分子影像重点实验室
通讯作者	Yang, Fan; Hu, Zhenhua; Zhou, Jian
作者单位	1.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing, Peoples R China 2.Beihang Univ, Sch Engn Med, Beijing, Peoples R China 3.Beihang Univ, Minist Ind & Informat Technol, Key Lab Big Data Based Precis Med, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Mi, Jiahui,Li, Changjian,Yang, Feng,et al. Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows[J]. ANNALS OF SURGICAL ONCOLOGY,2023:10.
APA	Mi, Jiahui.,Li, Changjian.,Yang, Feng.,Shi, Xiaojing.,Zhang, Zeyu.,...&Zhou, Jian.(2023).Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows.ANNALS OF SURGICAL ONCOLOGY,10.
MLA	Mi, Jiahui,et al."Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows".ANNALS OF SURGICAL ONCOLOGY (2023):10.