CASIA OpenIR  > 中国科学院分子影像重点实验室
Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows
Mi, Jiahui1; Li, Changjian2,3; Yang, Feng1; Shi, Xiaojing4,5; Zhang, Zeyu2,3; Guo, Lishuang2,3; Jiang, Guanchao1; Li, Yun1; Wang, Jun1; Yang, Fan1; Hu, Zhenhua4,5; Zhou, Jian1
Source PublicationANNALS OF SURGICAL ONCOLOGY
ISSN1068-9265
2023-12-08
Pages10
Corresponding AuthorYang, Fan(yangfan@pkuph.edu.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Zhou, Jian(zhoujian@bjmu.edu.cn)
AbstractBackground We compare the application of intravenous indocyanine green (ICG) fluorescence imaging in lung cancer with near-infrared-I (NIR-I) and near-infrared-II (NIR-II) windows.Methods From March to December 2022, we enrolled patients who received an intravenous injection of ICG (5 mg/kg) 1 day before the planned lung cancer surgery. The lung cancer nodules were imaged by NIR-I/II fluorescence imaging systems, and the tumor-to-normal-tissue ratio (TNR) was calculated. In addition, the fluorescence intensity and signal-to-background ratio (SBR) of capillary glass tubes containing ICG covered with different thicknesses of lung tissue were measured by NIR-I/II fluorescence imaging systems.Results In this study, 102 patients were enrolled, and the mean age was 59.9 +/- 9.2 years. A total of 96 (94.1%) and 98 (96.1%) lung nodules were successfully imaged with NIR-I and NIR-II fluorescence, and the TNR of NIR-II was significantly higher than that of NIR-I (3.9 +/- 1.3 versus 2.4 +/- 0.6, P < 0.001). In multiple linear regression, solid nodules (P < 0.001) and squamous cell carcinoma (P < 0.001) were independent predictors of a higher TNR of NIR-I/II. When capillary glass tubes were covered with lung tissue whose thickness was more than 2 mm, the fluorescence intensity and the SBR of NIR-II were significantly higher than those of NIR-I.Conclusions We verified the feasibility of NIR-II fluorescence imaging in intravenous ICG lung cancer imaging for the first time. NIR-II fluorescence can improve the TNR and penetration depth of lung cancer with promising clinical prospects.
KeywordIndocyanine green Near-infrared-II windows Fluorescence imaging Lung cancer surgery Clinical application
DOI10.1245/s10434-023-14677-9
WOS KeywordFLUOROPHORES ; NODULES ; IDENTIFICATION ; RESECTION
Indexed BySCI
Language英语
Funding ProjectCAS Youth Interdisciplinary Team ; National Natural Science Foundation of China[82003316] ; National Natural Science Foundation of China[92059203] ; National Natural Science Foundation of China[92059207] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; Fundamental Research Funds for the Central Universities[JKF-YG-22-B005] ; [JCTD-2021-08]
Funding OrganizationCAS Youth Interdisciplinary Team ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
WOS Research AreaOncology ; Surgery
WOS SubjectOncology ; Surgery
WOS IDWOS:001117873100008
PublisherSPRINGER
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/54968
Collection中国科学院分子影像重点实验室
Corresponding AuthorYang, Fan; Hu, Zhenhua; Zhou, Jian
Affiliation1.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing, Peoples R China
2.Beihang Univ, Sch Engn Med, Beijing, Peoples R China
3.Beihang Univ, Minist Ind & Informat Technol, Key Lab Big Data Based Precis Med, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Mi, Jiahui,Li, Changjian,Yang, Feng,et al. Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows[J]. ANNALS OF SURGICAL ONCOLOGY,2023:10.
APA Mi, Jiahui.,Li, Changjian.,Yang, Feng.,Shi, Xiaojing.,Zhang, Zeyu.,...&Zhou, Jian.(2023).Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows.ANNALS OF SURGICAL ONCOLOGY,10.
MLA Mi, Jiahui,et al."Comparative Study of Indocyanine Green Fluorescence Imaging in Lung Cancer with Near-Infrared-I/II Windows".ANNALS OF SURGICAL ONCOLOGY (2023):10.
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