| Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children | |
Wen, Hongwei1,2 ; Liu, Yue3,4; Wang, Jieqiong1; Rekik, Islem5; Zhang, Jishui3,4; Zhang, Yue3,4; Tian, Hongwei3,4; Peng, Yun3,4; He, Huiguang1,2
| |
| 发表期刊 | HUMAN BRAIN MAPPING
 |
| 2016-05-01 | |
| 卷号 | 37期号:5页码:1903-1919 |
| 文章类型 | Article |
| 摘要 | Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto-striato-thalamic pathways. In this study, we combined Tract-Based Spatial Statistics (TBSS) and Atlas-based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age- and gender-matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico-striato-thalamo-cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas-based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. Hum Brain Mapp 37:1903-1919, 2016. (c) 2016 Wiley Periodicals, Inc. |
| 关键词 | Tourette Syndrome Tract-based Spatial Statistics Atlas-based Roi Analysis Large Deformation Diffeomorphic Metric Mapping Superficial White Matter |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1002/hbm.23146 |
| 关键词[WOS] | DIFFUSION-TENSOR MRI ; BASAL GANGLIA ; STRUCTURAL CONNECTIVITY ; SPATIAL STATISTICS ; TIC DISORDERS ; AXONAL INJURY ; WHITE-MATTER ; BRAIN ; NETWORKS ; SCALE |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS and Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; 91520202 ; 31271161) |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000374840600019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/12211 |
| 专题 | 复杂系统管理与控制国家重点实验室_影像分析与机器视觉 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China 3.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China 4.Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Magnet Imaging Device & Tech, Beijing, Peoples R China 5.Univ N Carolina, Dept Radiol & BRIC, Chapel Hill, NC USA |
| 第一作者单位 | 中国科学院自动化研究所; 类脑智能研究中心 |
| 推荐引用方式 GB/T 7714 | Wen, Hongwei,Liu, Yue,Wang, Jieqiong,et al. Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children[J]. HUMAN BRAIN MAPPING,2016,37(5):1903-1919. |
| APA | Wen, Hongwei.,Liu, Yue.,Wang, Jieqiong.,Rekik, Islem.,Zhang, Jishui.,...&He, Huiguang.(2016).Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children.HUMAN BRAIN MAPPING,37(5),1903-1919. |
| MLA | Wen, Hongwei,et al."Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children".HUMAN BRAIN MAPPING 37.5(2016):1903-1919. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 发表的Human brain mappi（3757KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论