Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children
Wen, Hongwei1,2; Liu, Yue3,4; Wang, Jieqiong1; Rekik, Islem5; Zhang, Jishui3,4; Zhang, Yue3,4; Tian, Hongwei3,4; Peng, Yun3,4; He, Huiguang1,2
Source PublicationHUMAN BRAIN MAPPING
2016-05-01
Volume37Issue:5Pages:1903-1919
SubtypeArticle
AbstractTourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto-striato-thalamic pathways. In this study, we combined Tract-Based Spatial Statistics (TBSS) and Atlas-based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age- and gender-matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico-striato-thalamo-cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas-based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. Hum Brain Mapp 37:1903-1919, 2016. (c) 2016 Wiley Periodicals, Inc.
KeywordTourette Syndrome Tract-based Spatial Statistics Atlas-based Roi Analysis Large Deformation Diffeomorphic Metric Mapping Superficial White Matter
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23146
WOS KeywordDIFFUSION-TENSOR MRI ; BASAL GANGLIA ; STRUCTURAL CONNECTIVITY ; SPATIAL STATISTICS ; TIC DISORDERS ; AXONAL INJURY ; WHITE-MATTER ; BRAIN ; NETWORKS ; SCALE
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS and Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; 91520202 ; 31271161)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000374840600019
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12211
Collection复杂系统管理与控制国家重点实验室_影像分析与机器视觉
Affiliation1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China
3.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Magnet Imaging Device & Tech, Beijing, Peoples R China
5.Univ N Carolina, Dept Radiol & BRIC, Chapel Hill, NC USA
First Author AffilicationChinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China;  Institute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wen, Hongwei,Liu, Yue,Wang, Jieqiong,et al. Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children[J]. HUMAN BRAIN MAPPING,2016,37(5):1903-1919.
APA Wen, Hongwei.,Liu, Yue.,Wang, Jieqiong.,Rekik, Islem.,Zhang, Jishui.,...&He, Huiguang.(2016).Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children.HUMAN BRAIN MAPPING,37(5),1903-1919.
MLA Wen, Hongwei,et al."Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children".HUMAN BRAIN MAPPING 37.5(2016):1903-1919.
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