Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy

doi:10.21037/jtd.2016.06.02

	Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy
	Li, Hao 1; Zhou, Jian 1; Chi, Chongwei2 ; Mao, Yamin2 ; Yang, Fan 1; Tian, Jie 2; Wang, Jun 1
发表期刊	JOURNAL OF THORACIC DISEASE
	2016-07-01
卷号	8 期号:7 页码:1841-1845
文章类型	Article
摘要	Failure to identify all the possible bullous lesions was considered an important reason for the higher recurrence rate after the VATS bullectomy. We applied the latest near-infrared (NIR) thoracoscope with indocyanine green (ICG) to detect bullous lesions for patients with spontaneous pneumothorax. Two male patients with spontaneous pneumothorax and poorly identified bullae intraoperatively were included in this pilot study. An NIR thoracoscope with two different doses of ICG injection (0.2 and 0.6 mg/kg) was used to detect bullous lesions during VATS bullectomy. Partial lung resections of the bullous lesions were performed under syncretic mode. Data was managed with ImageJ software. No procedure-related complications were observed. The fluorescent signal was detected in normal lung tissue 10.5 seconds (mean, 10-11 seconds) after the ICG bolus, and lasted up to 525 seconds (mean, 480-570 seconds). The bullous lesions showed an obviously decreased fluorescent densities comparing to adjacent normal tissue. At the dosage of 0.6 mg/kg, ICG emits sufficient fluorescence to demonstrate the precise border of bullae, with the max SBR of 6.32. All resected specimens were confirmed as bullous lesions microscopically. NIR thoracoscope with intravenous ICG is a safe, accurate and real-time method to detect bullous lesions of lung tissue difficult to be found under normal light in human subjects.
关键词	Thoracoscopy/vats Emphysema/bullae Pneumothorax
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.21037/jtd.2016.06.02
关键词[WOS]	SURGERY ; LUNG
收录类别	SCI
语种	英语
项目资助者	Peking University People's Hospital Research and Development Foundation(RDC2015-33)
WOS研究方向	Respiratory System
WOS类目	Respiratory System
WOS记录号	WOS:000385021800115
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/13339
专题	中国科学院分子影像重点实验室
作者单位	1.Peking Univ, Peoples Hosp, Ctr Thorac Miniinvas Surg, Dept Thorac Surg, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100044, Peoples R China
推荐引用方式 GB/T 7714	Li, Hao,Zhou, Jian,Chi, Chongwei,et al. Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy[J]. JOURNAL OF THORACIC DISEASE,2016,8(7):1841-1845.
APA	Li, Hao.,Zhou, Jian.,Chi, Chongwei.,Mao, Yamin.,Yang, Fan.,...&Wang, Jun.(2016).Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy.JOURNAL OF THORACIC DISEASE,8(7),1841-1845.
MLA	Li, Hao,et al."Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy".JOURNAL OF THORACIC DISEASE 8.7(2016):1841-1845.

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