In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector

doi:10.1109/LMAG.2023.3281933

	In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector
	Hui, Hui1,2,3 ; Liu, Jiaojiao 4; Zhang, Hui5,6 ; Zhong, Jing 7; He, Jie 5,6; Zhang, Bo 5,6; Zhang, Haoran 5,6; Li, Qin 8; Li, Hongjun 4; Tian, Jie 1,2,5,6,9
发表期刊	IEEE MAGNETICS LETTERS
ISSN	1949-307X
	2023
卷号	14 页码:5
通讯作者	Li, Qin(liqin2@motac.com) ; Li, Hongjun(lihongjun00113@ccmu.edu.cn) ; Tian, Jie(tian@ieee.org)
摘要	The purpose of this study is to develop a magnetic particle imaging (MPI) technique to directly measure time-varied cerebral superparamagnetic iron oxide nanoparticle (SPIO) concentration in rhesus macaques. A hand-held MPI detector was developed to monitor MPI signal changes at the third harmonics of the drive frequency in resting-state nonhuman primates. Phantom experiments were first performed to determine the sensitivity limits of the detector as a function of distance from the detector and SPIO concentration. The measured sensitivity profile was then used to reveal the most sensitive region of the detector. MPI detection was continuously performed to monitor MPI signal changes after two bolus injections of SPIOs in the rhesus macaque. We successfully developed a hand-held MPI to detect cerebral SPIO concentration changes in a living nonhuman primate. The detection limit of the MPI detector is about 125 ng iron. We reported on the in vivo measurement of cerebral SPIO concentration changes in rhesus macaque using a hand-held MPI detector. In vivo experiments showed the feasibility of the detector to sensitively measure MPI signals in a nonhuman primate brain.
关键词	Magnetic instruments cerebral blood volume magnetic particle imaging nonhuman primate superparamagnetic iron oxide nanoparticles
DOI	10.1109/LMAG.2023.3281933
关键词[WOS]	BLOOD-VOLUME ; CONTRAST AGENT ; FMRI ; TOMOGRAPHY ; TRACERS ; MOTION ; AWAKE ; BOLD
收录类别	SCI
语种	英语
资助项目	Beijing Natural Science Foundation[JQ22023] ; Beijing Natural Science Foundation[7212051] ; Beijing Natural Science Foundation[L222097] ; National Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[Z211100003521003] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[61936013] ; National Natural Science Foundation of China[81771806] ; National Natural Science Foundation of China[81227901] ; CAS Youth Innovation Promotion Association[Y2022055] ; CAS Key Technology Talent Program
项目资助者	Beijing Natural Science Foundation ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Youth Innovation Promotion Association ; CAS Key Technology Talent Program
WOS研究方向	Engineering ; Physics
WOS类目	Engineering, Electrical & Electronic ; Physics, Applied
WOS记录号	WOS:001025460700001
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53862
专题	中国科学院分子影像重点实验室
通讯作者	Li, Qin; Li, Hongjun; Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 4.Capital Med Univ, Beijing Youan Hosp, Dept Radiol, Beijing 100069, Peoples R China 5.Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China 6.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China 7.Beihang Univ, Sch Instrumentat & Optoelect Engn, Beijing 100191, Peoples R China 8.Motac Beijing Serv Ltd, Beijing 100050, Peoples R China 9.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol China, Beijing 100191, Peoples R China
第一作者单位	中国科学院自动化研究所; 中国科学院分子影像重点实验室
通讯作者单位	中国科学院自动化研究所; 中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Hui, Hui,Liu, Jiaojiao,Zhang, Hui,et al. In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector[J]. IEEE MAGNETICS LETTERS,2023,14:5.
APA	Hui, Hui.,Liu, Jiaojiao.,Zhang, Hui.,Zhong, Jing.,He, Jie.,...&Tian, Jie.(2023).In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector.IEEE MAGNETICS LETTERS,14,5.
MLA	Hui, Hui,et al."In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector".IEEE MAGNETICS LETTERS 14(2023):5.