Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children
Wen, Hongwei1,3; Liu, Yue4; Rekik, Islem5; Wang, Shengpei1,3; Zhang, Jishui6; Zhang, Yue4; Peng, Yun4; He, Huiguang1,2,3; He HG(何晖光)
2017-08-01
发表期刊HUMAN BRAIN MAPPING
卷号38期号:8页码:3988-4008
文章类型Review
摘要Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder. Although previous TS studies revealed structural abnormalities in distinct corticobasal ganglia circuits, the topological alterations of the whole-brain white matter (WM) structural networks remain poorly understood. Here, we used diffusion MRI probabilistic tractography and graph theoretical analysis to investigate the topological organization of WM networks in 44 drug-naive TS children and 41 age- and gender-matched healthy children. The WM networks were constructed by estimating inter-regional connectivity probability and the topological properties were characterized using graph theory. We found that both TS and control groups showed an efficient small-world organization in WM networks. However, compared to controls, TS children exhibited decreased global and local efficiency, increased shortest path length and small worldness, indicating a disrupted balance between local specialization and global integration in structural networks. Although both TS and control groups showed highly similar hub distributions, TS children exhibited significant decreased nodal efficiency, mainly distributed in the default mode, language, visual, and sensorimotor systems. Furthermore, two separate networks showing significantly decreased connectivity in TS group were identified using network-based statistical (NBS) analysis, primarily composed of the parieto-occipital cortex, precuneus, and paracentral lobule. Importantly, we combined support vector machine and multiple kernel learning frameworks to fuse multiple levels of network topological features for classification of individuals, achieving high accuracy of 86.47%. Together, our study revealed the disrupted topological organization of structural networks related to pathophysiology of TS, and the discriminative topological features for classification are potential quantitative neuroimaging biomarkers for clinical TS diagnosis. Hum Brain Mapp 38:3988-4008, 2017. (c) 2017 Wiley Periodicals, Inc.
关键词Tourette Syndrome Diffusion Mri Probabilistic Tractography Structural Network Graph Theory Topological Organization Multiple Kernel Learning
WOS标题词Science & Technology ; Life Sciences & Biomedicine
学科领域模式识别与智能系统
DOI10.1002/hbm.23643
关键词[WOS]ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; VOXEL-BASED MORPHOMETRY ; MAJOR DEPRESSIVE DISORDER ; DEFAULT MODE NETWORK ; WHITE-MATTER ; MULTIPLE-SCLEROSIS ; BASAL GANGLIA ; GRAPH-THEORY ; SMALL-WORLD ; MICROSTRUCTURAL ABNORMALITIES
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(91520202 ; Youth Innovation Promotion Association CAS ; Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; Beijing Health System Top Level Health Technical Personnel Training Plan(2015-3-082) ; 61271151 ; 31271161 ; 81671651)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000404963900016
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14659
专题复杂系统管理与控制国家重点实验室_影像分析与机器视觉
通讯作者He HG(何晖光)
作者单位1.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China
2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
5.Univ Dundee, Sch Sci & Engn, CVIP, Comp, Dundee, Scotland
6.Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Beijing, Peoples R China
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Wen, Hongwei,Liu, Yue,Rekik, Islem,et al. Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children[J]. HUMAN BRAIN MAPPING,2017,38(8):3988-4008.
APA Wen, Hongwei.,Liu, Yue.,Rekik, Islem.,Wang, Shengpei.,Zhang, Jishui.,...&何晖光.(2017).Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children.HUMAN BRAIN MAPPING,38(8),3988-4008.
MLA Wen, Hongwei,et al."Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children".HUMAN BRAIN MAPPING 38.8(2017):3988-4008.
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