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Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population | |
Liu, Shengfeng1,2,3,4,5; Wang, Haiying3; Song, Ming1,2; Lv, Luxian6,7; Cui, Yue1,2; Liu, Yong1,2; Fan, Lingzhong1,2; Zuo, Nianming1,2; Xu, Kaibin1,2; Du, Yuhui8,9; Yu, Qingbao8; Luo, Na1,2,4; Qi, Shile1,2,4; Yang, Jian10; Xie, Sangma1,2; Li, Jian1,2; Chen, Jun11; Chen, Yunchun12; Wang, Huaning12; Guo, Hua13; Wan, Ping13; Yang, Yongfeng6,7,14; Li, Peng15,16; Lu, Lin15,16,17; Yan, Hao15,16; Yan, Jun15,16; Wang, Huiling18; Zhang, Hongxing6,7,19; Zhang, Dai15,16,20; Calhoun, Vince D.8,21; Jiang, Tianzi1,2,4,17,22; Sui, Jing1,2,4,8,22 | |
发表期刊 | SCHIZOPHRENIA BULLETIN |
ISSN | 0586-7614 |
2019-03-01 | |
卷号 | 45期号:2页码:436-449 |
摘要 | Multimodal fusion has been regarded as a promising tool to discover covarying patterns of multiple imaging types impaired in brain diseases, such as schizophrenia (SZ). In this article, we aim to investigate the covarying abnormalities underlying SZ in a large Chinese Han population (307 SZs, 298 healthy controls [HCs]). Four types of magnetic resonance imaging (MRI) features, including regional homogeneity (ReHo) from resting-state functional MRI, gray matter volume (GM) from structural MRI, fractional anisotropy (FA) from diffusion MRI, and functional network connectivity (FNC) resulted from group independent component analysis, were jointly analyzed by a data-driven multivariate fusion method. Results suggest that a widely distributed network disruption appears in SZ patients, with synchronous changes in both functional and structural regions, especially the basal ganglia network, salience network (SAN), and the frontoparietal network. Such a multimodal coalteration was also replicated in another independent Chinese sample (40 SZs, 66 HCs). Our results on auditory verbal hallucination (AVH) also provide evidence for the hypothesis that prefrontal hypoactivation and temporal hyperactivation in SZ may lead to failure of executive control and inhibition, which is relevant to AVH. In addition, impaired working memory performance was found associated with GM reduction and FA decrease in SZ in prefrontal and superior temporal area, in both discovery and replication datasets. In summary, by leveraging multiple imaging and clinical information into one framework to observe brain in multiple views, we can integrate multiple inferences about SZ from large-scale population and offer unique perspectives regarding the missing links between the brain function and structure that may not be achieved by separate unimodal analyses. |
关键词 | multimodal fusion resting-state fMRI schizophrenia auditory hallucination functional network connectivity (FNC) structural MRI diffusion MRI MCCA plus jICA |
DOI | 10.1093/schbul/sby045 |
关键词[WOS] | AUDITORY HALLUCINATIONS ; FUNCTIONAL CONNECTIVITY ; 1ST-EPISODE SCHIZOPHRENIA ; WHITE-MATTER ; GRAY-MATTER ; ANTIPSYCHOTIC TREATMENT ; BIPOLAR DISORDER ; WORKING-MEMORY ; DIGIT SPAN ; FUSION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | NIH[P20GM103472] ; NIH[R01EB005846] ; NIH[1R01MH094524] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02060005] ; 100 Talents Plan of Chinese Academy of Sciences ; Natural Science Foundation of Shanxi[2016021077] ; Chinese National Science Foundation[81471367] ; Chinese National Science Foundation[61773380] ; Chinese National Science Foundation[61703253] ; National High-Tech Development Plan (863 program)[2015AA020513] ; NIH[P20GM103472] ; NIH[R01EB005846] ; NIH[1R01MH094524] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02060005] ; 100 Talents Plan of Chinese Academy of Sciences ; Natural Science Foundation of Shanxi[2016021077] ; Chinese National Science Foundation[81471367] ; Chinese National Science Foundation[61773380] ; Chinese National Science Foundation[61703253] ; National High-Tech Development Plan (863 program)[2015AA020513] |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000461163300023 |
出版者 | OXFORD UNIV PRESS |
七大方向——子方向分类 | 医学影像处理与分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/24993 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Sui, Jing |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Harbin Univ Sci & Technol, Sch Automat, Harbin, Heilongjiang, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Natl Reg Key Technol Engn Lab Med Ultrasound, Shenzhen, Peoples R China 6.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China 7.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 8.Mind Res Network, Albuquerque, NM USA 9.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China 10.Beijing Inst Technol, Sch Opt & Elect, Beijing Engn Res Ctr Mixed Real & Adv Display, Beijing, Peoples R China 11.Wuhan Univ, Renmin Hosp, Dept Radiol, Wuhan, Hubei, Peoples R China 12.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Shaanxi, Peoples R China 13.Zhumadian Psychiat Hosp, Zhumadian, Peoples R China 14.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu, Sichuan, Peoples R China 15.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China 16.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China 17.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 18.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Hubei, Peoples R China 19.Xinxiang Med Univ, Dept Psychol, Xinxiang, Peoples R China 20.Peking Univ, McGovern Inst Brain Res, PKU IDG, Ctr Life Sci, Beijing, Peoples R China 21.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA 22.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China |
第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
通讯作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室; 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Shengfeng,Wang, Haiying,Song, Ming,et al. Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population[J]. SCHIZOPHRENIA BULLETIN,2019,45(2):436-449. |
APA | Liu, Shengfeng.,Wang, Haiying.,Song, Ming.,Lv, Luxian.,Cui, Yue.,...&Sui, Jing.(2019).Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population.SCHIZOPHRENIA BULLETIN,45(2),436-449. |
MLA | Liu, Shengfeng,et al."Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population".SCHIZOPHRENIA BULLETIN 45.2(2019):436-449. |
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